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Oral and parenteral clindamycin, as well as most other antibiotics, have been associated with severe diarrhea and pseudomembranous colitis. Use of the topical formulation of clindamycin results in absorption of the antibiotic from the skin surface (see Pharmacology: Pharmacokinetics under Actions). Diarrhea and colitis have been reported infrequently with topical clindamycin. Therefore, the physician should be alert to the possible development of antibiotic-associated diarrhea or colitis. If significant or prolonged diarrhea occurs, the drug should be discontinued and appropriate diagnostic procedures and treatment provided as necessary. Large bowel endoscopy should be considered in cases of severe diarrhea. Antiperistaltic agents such as opiates and diphenoxylate with atropine may prolong and/or worsen the condition.
Effect on Ability to Drive and Use Machines: It is not expected that DALACIN T would interfere with the ability to drive or operate machinery.
